Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.

  title={Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.},
  author={D Kirchhofer and James Gailit and Erkki Ruoslahti and John J Grzesiak and Michael D. Pierschbacher},
  journal={The Journal of biological chemistry},
  volume={265 30},
The presence of manganese (Mn2+) significantly increases the binding of the platelet surface receptor GPIIb/IIIa to two synthetic peptides Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) and Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val (L10) that contain the recognition sequences RGD and KQAGDV, respectively. This results in an increase in the amount of GPIIb/IIIa adsorbed by GRGDSPK- and L10-Sepharose by 12-20-fold. Additionally, Mn2+ eliminates contaminating platelet vitronectin receptor, alpha v beta 3, which… CONTINUE READING
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