Cation channels trigger apoptotic death of erythrocytes

  title={Cation channels trigger apoptotic death of erythrocytes},
  author={Karl S Lang and Christophe Duranton and Holger Poehlmann and Svetlana Myssina and Christian R. K. D. Bauer and Florian Lang and Thomas Wieder and Stephan M Huber},
  journal={Cell Death and Differentiation},
AbstractErythrocytes are devoid of mitochondria and nuclei and were considered unable to undergo apoptosis. As shown recently, however, the Ca2+-ionophore ionomycin triggers breakdown of phosphatidylserine asymmetry (leading to annexin binding), membrane blebbing and shrinkage of erythrocytes, features typical for apoptosis in nucleated cells. In the present study, the effects of osmotic shrinkage and oxidative stress, well-known triggers of apoptosis in nucleated cells, were studied. Exposure… CONTINUE READING


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