Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells.

@article{Dietrich2006CationCO,
  title={Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells.},
  author={Alexander Dietrich and Vladimir Chubanov and Hermann Kalwa and Benjamin Rainer Rost and Thomas Gudermann},
  journal={Pharmacology & therapeutics},
  year={2006},
  volume={112 3},
  pages={744-60}
}
Smooth muscle cells (SMC) are essential components of many tissues of the body. Ion channels regulate their membrane potential, the intracellular Ca(2+) concentration ([Ca(2+)](i)) and their contractility. Among the ion channels expressed in SMC cation channels of the transient receptor potential (TRP) superfamily allow the entry of Na(+), Ca(2+) and Mg(2+). Members of the TRP superfamily are essential constituents of tonically active channels (TAC), receptor-operated channels (ROC), store… CONTINUE READING
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