Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis.

@article{Vandorpe2002CationCR,
  title={Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis.},
  author={David H. Vandorpe and Sabine Wilhelm and Lianwei Jiang and Oxana Ibraghimov-Beskrovnaya and Marina N. Chernova and Alan K. Stuart-Tilley and Seth L Alper},
  journal={Physiological genomics},
  year={2002},
  volume={8 2},
  pages={87-98}
}
Polycystin-1 (PKD1) mutations account for approximately 85% of autosomal dominant polycystic kidney disease (ADPKD). We have shown previously that oocyte surface expression of a transmembrane fusion protein encoding part of the cytoplasmic COOH terminus of PKD1 increases activity of a Ca2+-permeable cation channel. We show here that human ADPKD mutations… CONTINUE READING