Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype)

@inproceedings{Hannemann2015CationHI,
  title={Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype)},
  author={Anke Hannemann and D. C. Rees and Sanjay Tewari and John S Gibson},
  booktitle={EBioMedicine},
  year={2015}
}
  • Anke Hannemann, D. C. Rees, +1 author John S Gibson
  • Published in EBioMedicine 2015
  • Medicine
  • Sickle cell disease (SCD) in patients of HbSC genotype is considered similar, albeit milder, to that in homozygous HbSS individuals--but with little justification. In SCD, elevated red cell cation permeability is critical as increased solute loss causes dehydration and encourages sickling. Recently, we showed that the KCl cotransporter (KCC) activity in red cells from HbSC patients correlated significantly with disease severity, but that in HbSS patients did not. Two transporters involved in… CONTINUE READING

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