Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect

@article{Kalix2004CathinoneAA,
  title={Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect},
  author={Peter Kalix},
  journal={Psychopharmacology},
  year={2004},
  volume={74},
  pages={269-270}
}
  • P. Kalix
  • Published 2004
  • Biology
  • Psychopharmacology
Khat leaves, widely used as a stimulant in East Africa and the Arab Peninsula, contain the alkaloid (-)-cathinone. The effects of this substance on the efflux of radioactivity from rabbit striatal slices prelabelled with 3H-dopamine were examined. It was found that low concentrations of (-)cathinone enhance the release of radioactivity in a dose-dependent manner, and that (-)cathinone was capable of sustaining the enhanced release induced by (+)amphetamine. Pretreatment of the tissue with… 

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The effects of (−)‐cathinone on the locomotor behaviour of hypophysectomized rats was analogous to that reported for (+)‐amphetamine in such animals, and support the claim that the symptoms caused by the chewing of khat are amphetamine‐like.

Hyperthermic response to (—)‐cathinone, an alkaloid of Catha edulis (khat)

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Recently, a new khat alkaloid of the phenylethylamine type has been identified and the name (-)-cathinone has been proposed (UN document 1975; Schorno & Steinegger 1979). Most of the symptoms

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