Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner.

@article{AdeoyaOsiguwa2007CathineAA,
  title={Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner.},
  author={Susan A. Adeoya-Osiguwa and Lynn R. Fraser},
  journal={Human reproduction},
  year={2007},
  volume={22 3},
  pages={
          756-65
        }
}
BACKGROUND Mammalian spermatozoa have been shown to have beta(1,2,3)- and alpha(2A)-adrenergic receptors, the former functioning only in uncapacitated spermatozoa and the latter only in capacitated cells. Cathine, an amphetamine-related metabolite of a compound found in Catha edulis leaves, accelerates capacitation and inhibits spontaneous acrosome loss by regulating cAMP production. This study tested the hypothesis that adrenergic receptors are involved in these responses. METHODS… Expand
Adenosine and Catecholamine Agonists Speed the Flagellar Beat of Mammalian Sperm by a Non-Receptor-Mediated Mechanism1
TLDR
The results show that adenosine and catecholamine agonists act in a novel signaling pathway that does not involve G protein-coupled cell-surface receptors that link to conventional adenylyl cyclases and may be transported into sperm via equilibrative and concentrative nucleoside transporters to act on unknown intracellular targets. Expand
Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
TLDR
It is shown that several psychostimulants and hallucinogens are substrates for OCTs, including mescaline, which could be a reason for highly variable adverse reactions. Expand
Presence and Function of Dopamine Transporter (DAT) in Stallion Sperm: Dopamine Modulates Sperm Motility and Acrosomal Integrity
TLDR
It is demonstrated that acrosome integrity and thyrosine phosphorylation in equine sperm is significantly reduced at high concentrations of this catecholamine, and that the dopamine uptake by DAT can regulate sperm function, specifically acrosomal integrity and sperm motility. Expand
Regulatory properties of adenylyl and guanylyl cyclase in human spermatozoa
TLDR
The sensitivity of AC and GC to hormones in the common pool of ES and in the fraction of highly motile FS isolated by centrifugation was essentially different, which is to be considered when using FS for accessory reproductive technology. Expand
The role of Zn-alpha2 glycoprotein in sperm motility is mediated by changes in cyclic AMP.
TLDR
Using computer-assisted sperm analysis, data suggest that ZAG is present in human spermatozoa and may be involved in the regulation of sperm motility via the cAMP/PKA signaling pathway. Expand
Alteration of catecholamine concentrations in rat testis after methamphetamine exposure
TLDR
Rat models of METH abuse could induce changes in the dopamine metabolite 3,4‐dihydroxyphenylacetic acid, norepinephrine and its metabolite, DHPG, in testis that may result in male reproductive dysfunction. Expand
Functional activity of adenylyl and guanylyl cyclases in human spermatozoa with different motility
TLDR
It is concluded that the change in proportion of motile spermatozoa in ejaculate induces changes of functional activity and regulatory properties of soluble and membrane-bound forms of AC and GC, which can be used to control the motility, chemotaxis, acrosomal reaction, and other processes determining fertility of male germ cells. Expand
Neuronal signaling repertoire in the mammalian sperm functionality
TLDR
The aim of this review is to present an overview of sperm functionality associated with “neuronal signaling” and possible cellular and molecular mechanisms involved in their regulation. Expand
The potential influence of plant-based feed supplements on sperm quantity and quality in livestock: a review.
TLDR
The review focuses on the impact of oxidative stress on sperm production and quality in livestock, and the potential role of plant based anti-oxidants to control this impact, and considers the potential usefulness of medicinal herbs. Expand
Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease.
TLDR
Current progress in understanding of the role membrane trafficking plays in location control of GPCR signaling is discussed, from organized plasma membrane signaling microdomains, potentially provided by both distinct endocytic and exocytic pathways, to more recent evidence for spatial control within the endomembrane system. Expand
...
1
2
...

References

SHOWING 1-10 OF 55 REFERENCES
Identification of functional α2- and β-adrenergic receptors in mammalian spermatozoa
TLDR
These experiments provide the first good evidence that mammalian spermatozoa have both beta-adrenergic receptors, known to stimulate cAMP production by membrane-associated adenylyl cyclases (mACs), and alpha1- and alpha2-receptors,known to inhibit cAMPProduction by mACs. Expand
Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss.
TLDR
This is the first demonstration that PPAs can directly affect mammalian sperm function, accelerating capacitation and inhibiting spontaneous acrosome reactions (ARs) but progesterone could over-ride this inhibition. Expand
In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
TLDR
The data indicate that the pharmacological effects of ephedrine-like phenylpropanolamines are likely mediated by norepinephrine release, and although sharing mechanistic similarities with, they differ in important respects from those of the phenyl Propanonamines methcathinone and cathin one and the phenyisopropylamines methamphetamine and amphetamine. Expand
Signaling Pathways for Modulation of Mouse Sperm Motility by Adenosine and Catecholamine Agonists1
TLDR
Results show that adenosine and catecholamine analogs activate sperm motility by mechanisms that require extracellular Ca2+, the atypical sperm adenylyl cyclase, cAMP, and protein kinase A. Expand
Capacitation state‐dependent changes in adenosine receptors and their regulation of adenylyl cyclase/cAMP
TLDR
Results indicate that specific adenosine receptors function in a reversible manner in one or other capacitation state, resulting in regulation of cAMP. Expand
Cathinone, a natural amphetamine.
  • P. Kalix
  • Chemistry, Medicine
  • Pharmacology & toxicology
  • 1992
TLDR
Much experimental evidence indicates that cathinone is the main psychoactive constituent of the khat leaf and that, in fact, this alkaloid is a natural amphetamine. Expand
Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH‐related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro
TLDR
It is proposed that this prostatic tripeptide with structural similarities to thyrotrophin‐releasing hormone be referred to as fertilization promoting peptide (FPP), because it is possible that it plays a similar role in vivo and promotes fertilizing ability of ejaculated spermatozoa. Expand
Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function
TLDR
Calcitonin, like FPP, acts as a first messenger to regulate the production of cAMP and mammalian sperm function, but the differences in Ca2+ requirements suggest that calcitonin and FPP may regulate different isoforms of adenylyl cyclase. Expand
A possible mechanism of action for fertilization promoting peptide, a TRH‐related tripeptide that promotes capacitation and fertilizing ability in mammalian spermatozoa
TLDR
It is suggested that FPP and adenosine, by modulating adenylate cyclase activity to promote capacitation but inhibit spontaneous acrosomal exocytosis, may provide an endogenous mechanism that helps to optimize the fertilizing potential of the few sperm cells that reach the site of fertilization in vivo. Expand
Angiotensin II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa.
TLDR
The hypothesis that AII stimulates AC/cAMP in mammalian spermatozoa is supported by results support the hypothesis that these peptides act on the same pathway. Expand
...
1
2
3
4
5
...