Catherine Ulbricht, PharmD, MBA(C), Column Editor Lemon Balm (Melissa officinalis L.)

  title={Catherine Ulbricht, PharmD, MBA(C), Column Editor Lemon Balm (Melissa officinalis L.)},
  author={Thomas Brendler and Joerg Gruenwald and Benjamin Kligler and David Keifer and Tracee Rae Abrams and Jen Woods and Heather S. Boon and Catherine Defranco Kirkwood and Ethan M. Basch and Hope J. Lafferty and Catherine E. Ulbricht and Dana A. Hackman},
  journal={Journal Of Herbal Pharmacotherapy},
  pages={114 - 71}
An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. 
Melissa officinalis L: A Review Study With an Antioxidant Prospective
Traditional usage of this herb was reviewed, including antimicrobial activity (antiparasitic, antibacterial, antiviral, etc), antispasmodic, and insomnia properties, and its antioxidant properties were overviewed.
Bioassay‐guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity
A novel pharmacological mechanism of action for the anxiolytic botanical Melissa officinalis L. (lemon balm) is reported. The methanol extract was identified as a potent in vitro inhibitor of rat
Review on Lemon Balm Herb and its Evaluation
Evaluated phytochemical screening of ethanolic extract of Melissa officinalis L. elicited a significant dose-dependent reduction in both inhibitory and excitatory transmission, which may help to find novel therapeutic agents in the treatment of anxiety.
The Effects of Lemon balm ( Melissa officinalis L.) Alone and in Combination With Nepeta menthoides on the Menstrual Bleeding in Students With Premenstrual Syndrome: A Randomized Controlled Trial
Treatment with Lemon balm and lemon balm N. menthoides herbs did not decrease menstrual bleeding in students with premenstrual syndrome, and further clinical studies should be performed to assess the efficacy of lemon Balm and N. Menthoides in reproductive women to determine whether this medication is appropriate for treatment in the clinical setting.
Effect of Melissa officinalis (Lemon balm) on Sexual Dysfunction in Women: A Double- blind, Randomized, Placebo-controlled Study
M. officinalis may be a safe and effective herbal medicine for the improvement of HSDD in women.
Toxic essential oils, part VI: Acute oral toxicity of lemon balm (Melissa officinalis L.) essential oil in BALB/c mice.
Anticonvulsant effects of hydroalcoholic extract of Melissa officinalis on pentylenetetrazole (PTZ) model of convulsion in mice
Analysis of anticonvulsant activity of the hydroalcoholic extract of M. officinalis shows that it can be useful for treatment of seizure, and onset time of convulsive symptoms increases by doses increasing which may indicate the dose-dependent effect of the extract.


[Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare].
Twenty four patients with chronic non-specific colitis were treated with a herb combination and the spontaneous and palpable pains along the large intestine disappeared in 95.83 per cent of the patients by the 15th day of their admission to the clinic.
Melissa officinalis L. essential oil: antitumoral and antioxidant activities
An in‐vitro cytotoxicity assay using MTT indicated that this oil was very effective against a series of human cancer cell lines, and results pointed to the potential use of M. officinalis essential oil as an antitumoral agent.
Melitric Acids A and B, New Trimeric Caffeic Acid Derivatives from Melissa officinalis
Two new polyphenolic compounds, melitric acids A (2) and B (5), were isolated from the aboveground part of Melissa officinalis (Labiatae) and their structures, consisting of three caffeic acid units,
Antiviral Activity of Melissa officinalis (Lemon Balm) Extract.∗
  • R. CohenL. KuceraE. C. Herrmann
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1964
Summary Hot-water extracts of the plant Melissa officinalis (lemon balm herb), when injected into embryonated eggs, protect them against the lethal action of Semliki Forest, Newcastle, vaccinia, and
Antimicrobial activity of essences from labiates.
All three essences possessed a similar degree of activity against the micro-organisms tested, though a relatively higher activity was seen in the case of M. officinalis.
Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination.
The cytoprotective effect of the extracts could be partly due to their flavonoid content and to their free radical scavenging properties, and the anti-ulcerogenic activity was also confirmed histologically.
The effect of the Melissa officinalis extract on immune response in mice.
The present results confirm the effect of water extracts from leaves of Melissa on the immune system, in both humoral and cellular response.
Antiherpes effect of Melissa officinalis L. extracts.
No significant values of inhibiting activity of M1, M2, and M3 on the same virus in vitro or in vivo were demonstrated, and the presence of caffeic, rosmarinic and ferulic acids was demonstrated by thin-layer chromatography.
Potential value of plants as sources of new antifertility agents I.
The preovulatory, preimplantation, and postIMplantation antifertility mechanisms of plant substances affecting the hypothalamus-pituitary, ovary, oviduct, uterus, or vagina are discussed in terms of reproductive differences among laboratory animal species.