Cathepsins: fundamental effectors of endolysosomal proteolysis.

  title={Cathepsins: fundamental effectors of endolysosomal proteolysis.},
  author={Sonia Guha and Harish Padh},
  journal={Indian journal of biochemistry & biophysics},
  volume={45 2},
Intracellular protein degradation is a universal feature of eukaryotic cells and vital for nutrition, protein turnover, intracellular signaling, development and other major physiological processes like antigen presentation and immunity. One of the major compartments of intracellular proteolysis is the endosome-lysosome system. The latter offers a highly orchestrated, vesicular pathway for protein transport and ultimate degradation in lysosomes. Though lysosomes are the classical organelles of… CONTINUE READING