Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.

  title={Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.},
  author={Yoshiyuki Yasuda and Zhenqiang Li and Doron Greenbaum and Matthew S Bogyo and Ekkehard Weber and Dieter Br{\"o}mme},
  journal={The Journal of biological chemistry},
  volume={279 35},
Atherosclerosis is characterized by a thickening and loss of elasticity of the arterial wall. Loss of elasticity has been attributed to the degradation of the arterial elastin matrix. Cathepsins K and S are papain-like cysteine proteases with known elastolytic activities, and both enzymes have been identified in macrophages present in plaque areas of diseased blood vessels. Here we demonstrate that macrophages express a third elastolytic cysteine protease, cathepsin V, which exhibits the most… CONTINUE READING


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Publications referenced by this paper.

Atherosclerosis 78, 69–79 Elastolytic Activity of Cathepsin V

K. Murata, Y. Yokoyama

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