Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.

Abstract

The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally implicated, we demonstrated that selective cathepsin S deficiency impaired angiogenesis and tumor cell proliferation, thereby impairing… (More)

Topics

Cite this paper

@article{Wang2006CathepsinSC, title={Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.}, author={Bing Wang and Jiusong Sun and Shiro Kitamoto and Min Yang and Anders Grubb and Harold A Chapman and Raghu Kalluri and G. R. Shi}, journal={The Journal of biological chemistry}, year={2006}, volume={281 9}, pages={6020-9} }