Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.

  title={Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.},
  author={Kristi M. Porter and Friedrich A. Wieser and Catera L. Wilder and Neil Sidell and Manu O. Platt},
  journal={Reproductive sciences},
  volume={23 5},
Endometriosis is a gynecologic disease characterized by the ectopic presence of endometrial tissue on organs within the peritoneal cavity, causing debilitating abdominal pain and infertility. Current treatments alleviate moderate pain symptoms associated with the disorder but exhibit limited ability to prevent new or recurring lesion establishment and growth. Retrograde menstruation has been implicated for introducing endometrial tissue into the peritoneal cavity, but molecular mechanisms… CONTINUE READING