Cathepsin L targeting in cancer treatment.


Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies seeking to impede cancer progression and metastasis. One such enzyme is cathepsin L (CTSL), a lysosomal cysteine protease. CTSL upregulation, a common occurrence in a variety of human cancers, has been widely correlated with metastatic aggressiveness and poor… (More)
DOI: 10.1016/j.pharmthera.2015.08.007


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@article{Sudhan2015CathepsinLT, title={Cathepsin L targeting in cancer treatment.}, author={Dhivya R. Sudhan and Dietmar W. Siemann}, journal={Pharmacology & therapeutics}, year={2015}, volume={155}, pages={105-16} }