Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.

@article{Primon2017CathepsinLS,
  title={Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.},
  author={Monika Primon and Peter Csaba Huszthy and Helena Motaln and Krishna M. Talasila and Hrvoje Miletic and Nadia A. Atai and Rolf Bjerkvig and Tamara Lah Turn{\vs}ek},
  journal={Experimental cell research},
  year={2017},
  volume={356 1},
  pages={64-73}
}
Low-grade, pilocytic astrocytomas are treated by resection, but additional therapy is necessary for those tumors with anaplastic features. Arsenic trioxide (As2O3) is emerging as an effective chemotherapeutic agent for treatment of malignant glioblastoma multiforme, where Cathepsin L silencing enables lower, less harmful As2O3 concentrations to achieve the desired cytotoxic effect. Here, we evaluated the effects of As2O3 combined with stable Cathepsin L shRNA silencing on cell viability… CONTINUE READING
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