Cathepsin L-like genes of Trypanosoma vivax from Africa and South America--characterization, relationships and diagnostic implications.

@article{Cortez2009CathepsinLG,
  title={Cathepsin L-like genes of Trypanosoma vivax from Africa and South America--characterization, relationships and diagnostic implications.},
  author={Alane P. Cortez and Adriana Carlos Rodrigues and Herakles Antonio Garcia and Lu{\'i}s C B G Neves and Jael Soares Batista and Zacharia Bengaly and Fernando Paiva and Marta M. G. Teixeira},
  journal={Molecular and cellular probes},
  year={2009},
  volume={23 1},
  pages={44-51}
}
We characterized sequences from genes encoding cathepsin L-like (CatL-like) cysteine proteases from African and South American isolates of Trypanosoma vivax and T. vivax-like organisms, and evaluated their suitability as genetic markers for population structure analysis and diagnosis. Phylogenetic analysis of sequences corresponding to CatL-like catalytic domains revealed substantial polymorphism, and clades of sequences (TviCatL1-9) were separated by large genetic distances. TviCatL1-4… CONTINUE READING