Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

@article{Wartmann2010CathepsinLI,
  title={Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.},
  author={Thomas Wartmann and Julia V Mayerle and Thilo K{\"a}hne and Mikl{\'o}s Sahin-T{\'o}th and Manuel Ruthenb{\"u}rger and Rainer Matthias and Anne Kruse and Thomas Reinheckel and Christoph Peters and Frank Ulrich Weiss and Matthias Sendler and Hans Lippert and H Schulz and Ali Aghdassi and Annegret Dummer and Steffen Teller and Walter Halangk and Markus M. Lerch},
  journal={Gastroenterology},
  year={2010},
  volume={138 2},
  pages={726-37}
}
BACKGROUND & AIMS Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB). We investigated whether cathepsin L (CTSL) can also process trypsinogen to active trypsin and has a role in pancreatitis. METHODS In CTSL-deficient (Ctsl(-/-)) mice, pancreatitis was induced by injection of cerulein or infusion of taurocholate into the pancreatic duct. Human… CONTINUE READING

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Release of cathepsin B into cytosol induces apoptosis in pancreatic acinar cells through mitochondrial pathways during pancreatitis

R Dawra, R Talukdar, V Dudeja
Gastroenterology • 2009

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