Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.

Abstract

The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The inflammatory arterial diseases abdominal aortic aneurysm (AAA) and atherosclerosis involve extensive vascular remodeling that requires… (More)

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