Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits.

  title={Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits.},
  author={Brenda L. Pennypacker and Le Thi Duong and Tara E. Cusick and Patricia J Masarachia and Michael A Gentile and Jacques-Yves Gauthier and W. Cameron Black and Boyd B. Scott and Rana Samadfam and Susan Y. Smith and Donald B. Kimmel},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={26 2},
Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ovariectomized (OVX) rabbits. The OVX model was validated by demonstrating significant loss (9.8% to 12.8%) in lumbar vertebral bone mineral density (LV BMD) in rabbits at 13-weeks after surgery, which was prevented by estrogen or ALN. A potent CatKI, L-006235 (L-235), dosed at 10 mg/kg per day for 27 weeks, significantly decreased LV BMD loss (p < .01) versus OVX… CONTINUE READING
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