Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

@article{Wang2004CathepsinKI,
  title={Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.},
  author={Dong Wang and Wentian Li and Michal Pechar and Pavla Kope{\vc}kov{\'a} and Dieter Br{\"o}mme and Jindřich Kope{\vc}ek},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={277 1-2},
  pages={73-9}
}
The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.