Corpus ID: 26652533

Cathepsin K inhibitor , icariin , increases the healing potential and biomechanical properties of femoral neck in a mice fractured model

@inproceedings{Jiang2016CathepsinKI,
  title={Cathepsin K inhibitor , icariin , increases the healing potential and biomechanical properties of femoral neck in a mice fractured model},
  author={Yuan-tao Jiang and Zhiguo Ma and Jian-bao Jiao and Zhao Guo and Li-gang Qian and Tao-ping Chen and Qing-gui Li and Yun-fei Wang and Jin-wei Xue},
  year={2016}
}
Cathepsin K inhibitors have been demonstrated to restore bone mass in both animal model and postmenopausal osteoporotic patients. In the present study, we performed to investigate the pharmacological effect of icariin in the healing potential and biomechanical properties of femoral neck in a mice fractured model. The results showed that the mRNA and protein expression of cathepsin K was markedly up-regulated in FNF group as compared to control group. However, icariin treatment could reverse the… Expand
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