Cathepsin K gene disruption does not affect murine aneurysm formation.

  title={Cathepsin K gene disruption does not affect murine aneurysm formation.},
  author={Lili Bai and L. J. Beckers and Erwin Wijnands and Suzanne P. M. Lutgens and M Ver{\'o}nica Her{\'i}as and Paul Saftig and Mat J. A. P. Daemen and Kitty B. J. M. Cleutjens and Esther Lutgens and Erik A. L. Biessen and Sylvia Heeneman},
  volume={209 1},
Cathepsin K (catK), a lysosomal cysteine protease, exerts strong elastinolytic and collagenolytic activity and is implicated in a range of pathological disorders including cardiovascular disease. CatK expression was found to be elevated in human aortic aneurysm pointing to a role in this vasculopathy. In the angiotensin II (Ang II)-induced mouse model for aneurysm formation, catK, S and C expression was strongly upregulated. Therefore, we investigated the effect of catK deficiency on Ang II… CONTINUE READING
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