Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

  title={Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.},
  author={Masataka Asagiri and Toshitake Hirai and Toshihiro Kunigami and Shunya Kamano and H J Gober and Kazuo Okamoto and Keizo Nishikawa and Eicke Latz and Douglas T Golenbock and Kazuhiro Aoki and Keiichi Ohya and Yuuki Imai and Yasuyuki Morishita and Kohei Miyazono and Shigeaki Kato and Paul Saftig and Hiroshi Takayanagi},
  volume={319 5863},
Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic potential. We show that inhibition of cathepsin K could potently suppress autoimmune inflammation of the joints as well as osteoclastic bone resorption in autoimmune arthritis. Furthermore, cathepsin K-/- mice were resistant to experimental autoimmune encephalomyelitis. Pharmacological inhibition or targeted disruption of cathepsin K resulted in… CONTINUE READING
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