Cathepsin K: a unique collagenolytic cysteine peptidase.

  title={Cathepsin K: a unique collagenolytic cysteine peptidase.},
  author={Marko Novinec and Brigita Lenar{\vc}i{\vc}},
  journal={Biological chemistry},
  volume={394 9},
Cathepsin K has emerged as a promising target for the treatment of osteoporosis in recent years. Initially identified as a papain-like cysteine peptidase expressed in high levels in osteoclasts, the important role of this enzyme in bone metabolism was highlighted by the finding that mutations in the CTSK gene cause the rare recessive disorder pycnodysostosis, which is characterized by severe bone anomalies. At the molecular level, the physiological role of cathepsin K is reflected by its unique… CONTINUE READING
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