Cathepsin G-Dependent Modulation of Platelet Thrombus Formation In Vivo by Blood Neutrophils

  title={Cathepsin G-Dependent Modulation of Platelet Thrombus Formation In Vivo by Blood Neutrophils},
  author={Nauder R Faraday and Kathryn J. Schunke and Sofiyan Saleem and Juan Fu and Bing Wang and Jian Zhang and Craig N. Morrell and Sylvain Dor{\'e}},
  booktitle={PloS one},
Neutrophils are consistently associated with arterial thrombotic morbidity in human clinical studies but the causal basis for this association is unclear. We tested the hypothesis that neutrophils modulate platelet activation and thrombus formation in vivo in a cathepsin G-dependent manner. Neutrophils enhanced aggregation of human platelets in vitro in dose-dependent fashion and this effect was diminished by pharmacologic inhibition of cathepsin G activity and knockdown of cathepsin G… CONTINUE READING
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