Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown.

@article{Dingle1971CathepsinDC,
  title={Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown.},
  author={John T. Dingle and Alan J. Barrett and P D Weston},
  journal={The Biochemical journal},
  year={1971},
  volume={123 1},
  pages={1-13}
}
1. Antisera were raised against lysosomal cathepsin D of man, chicken and rabbit. 2. The antisera were found to be specific and potent inhibitors of cathepsin D activity. 3. The immunological nature of the inhibition was established. 4. The inhibitory effect was studied by varying pH, antiserum/enzyme ratio, time of incubation, concentration of components and order of mixing, and by using purified antibody and univalent antibody fragments. 5. The specificities of the antisera were examined with… CONTINUE READING

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