Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.

@article{HuberLang2012CathepsinDI,
  title={Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.},
  author={Markus S Huber-Lang and Stephanie Denk and Simone Fulda and Ellen Erler and Miriam Kalbitz and Sebastian Weckbach and Elisabeth Marion Schneider and Manfred Weiss and Sandip M Kanse and Mario Perl},
  journal={Molecular immunology},
  year={2012},
  volume={50 1-2},
  pages={60-5}
}
In response to severe tissue trauma several danger sensing and signalling cascades are activated, including the complement and the apoptosis systems. In polytrauma patients, both the early activation of the complement cascade with an excessive generation of the potent anaphylatoxin C5a and the induction of apoptosis have been shown to modulate the post-traumatic immune response. However, little is known about a direct interaction between the complement and apoptosis systems after severe tissue… CONTINUE READING

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