Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.

@article{Koike2000CathepsinDD,
  title={Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.},
  author={Masato Koike and Hiroshi Nakanishi and Paul Saftig and Junji Ezaki and Kyoko Isahara and Yoshiyuki Ohsawa and Walter J. Schulz-Schaeffer and Takehiko Watanabe and Satoshi Waguri and Satoshi Kametaka and Mikihito Shibata and Kenji Hyogo Yamamoto and Eiki Kominami and Christoph Peters and Kurt von Figura and Yasuo Uchiyama},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 18},
  pages={
          6898-906
        }
}
Cathepsin D-deficient (CD-/-) mice have been shown to manifest seizures and become blind near the terminal stage [approximately postnatal day (P) 26]. We therefore examined the morphological, immunocytochemical, and biochemical features of CNS tissues of these mice. By electron microscopy, autophagosome/autolysosome-like bodies containing part of the cytoplasm, granular osmiophilic deposits, and fingerprint profiles were demonstrated in the neuronal perikarya of CD-/- mouse brains after P20… CONTINUE READING
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