Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.

Abstract

How, in the absence of a functional mannose 6-phosphate (Man-6-P)-signal-dependent transport pathway, some acid hydrolases remain sorted to endolysosomes in the brain is poorly understood. We demonstrate that cathepsin D binds to mouse SEZ6L2, a type 1 transmembrane protein predominantly expressed in the brain. Studies of the subcellular trafficking of… (More)
DOI: 10.1242/jcs.179374

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