Cathepsin D--many functions of one aspartic protease.

  title={Cathepsin D--many functions of one aspartic protease.},
  author={Petr Benes and V{\'a}clav Větvi{\vc}ka and Martin Fusek},
  journal={Critical reviews in oncology/hematology},
  volume={68 1},
For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice revealed that CD is not necessary for embryonal development, but it is indispensable for postnatal tissue homeostasis. Mutation that abolishes CD enzymatic activity causes neuronal ceroid lipofuscinosis (NCL) characterized by severe neurodegeneration, developmental regression, visual loss and epilepsy in both animals… CONTINUE READING
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