Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.

@article{Toomey2014CathepsinBR,
  title={Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.},
  author={Christopher B. Toomey and David M Cauvi and John C. Hamel and Andrea Estefan{\'i}a I{\~n}iguez Ramirez and Kenneth Michael Pollard},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={142 2},
  pages={
          339-49
        }
}
Susceptibility and resistance to systemic autoimmunity are genetically regulated. This is particularly true for murine mercury-induced autoimmunity (mHgIA) where DBA/2J mice are considered resistant to disease including polyclonal B cell activation, autoantibody responses, and immune complex deposits. To identify possible mechanisms for the resistance to mHgIA, we exposed mHgIA sensitive B10.S and resistant DBA/2J mice to HgCl2 and assessed inflammation and pro-inflammatory responses at the… CONTINUE READING
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