Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

@article{Nagaraj2005CathepsinBM,
  title={Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells},
  author={Nagathihalli S. Nagaraj and N Vigneswaran and Wolfgang Zacharias},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2005},
  volume={132},
  pages={171-183}
}
Purpose: The death ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand) triggers apoptosis in a variety of cancer cells, which implies the potential for therapeutic applications. The purpose of this study was to investigate the role of the lysosomal protease cathepsin B (CB) in mediating TRAIL-induced cell death in oral squamous cell carcinoma (OSCC) cells. Methods: OSCC cell lines from primary tumor and lymph node metastasis were examined for expression of apoptosis markers… CONTINUE READING

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