Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

  title={Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells},
  author={Nagathihalli S. Nagaraj and N Vigneswaran and Wolfgang Zacharias},
  journal={Journal of Cancer Research and Clinical Oncology},
Purpose: The death ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand) triggers apoptosis in a variety of cancer cells, which implies the potential for therapeutic applications. The purpose of this study was to investigate the role of the lysosomal protease cathepsin B (CB) in mediating TRAIL-induced cell death in oral squamous cell carcinoma (OSCC) cells. Methods: OSCC cell lines from primary tumor and lymph node metastasis were examined for expression of apoptosis markers… CONTINUE READING


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Publications referenced by this paper.
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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.

The Journal of biological chemistry • 2001
View 9 Excerpts
Highly Influenced

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

Nature Reviews Cancer • 2002
View 3 Excerpts
Highly Influenced

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