Cathepsin B-mediated activation of the proinflammatory caspase-11.

  title={Cathepsin B-mediated activation of the proinflammatory caspase-11.},
  author={Peter Schotte and Wim van Criekinge and Marc Van de Craen and Geert van Loo and Marjory Desmedt and Johan Grooten and Maria Cornelissen and Leo I F J M De Ridder and Jo{\"e}l Vandekerckhove and Walter Fiers and Peter Vandenabeele and Rudi Beyaert},
  journal={Biochemical and biophysical research communications},
  volume={251 1},
Members of the caspase (CASP) family of cysteine proteases can be subdivided in proapoptotic caspases and proinflammatory caspases. Whereas the apical activation pathways for the caspases that are involved in the execution of the apoptotic process are beginning to be understood, the pathways that lead to the activation of proinflammatory caspases are still largely unknown. Analysis of subcellular fractions for their ability to process and activate several caspases in vitro led to the… CONTINUE READING
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