Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats.

@article{Ellis2004CathepsinBM,
  title={Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats.},
  author={Rebecca C Ellis and J Nicole Earnhardt and Ronald L. Hayes and Kevin K. W. Wang and Douglas K. Anderson},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 3},
  pages={689-97}
}
We provide the first data that cathepsin B (Cath B), a lysosomal cysteine protease, is up-regulated following contusion-spinal cord injury (SCI). Following T12 laminectomy and moderate contusion, Cath B mRNA and protein expression profiles were examined from 2 to 168 h post-injury in rats using real-time PCR and immunoblots, respectively. Contusion injury significantly increased [mRNA]Cath B in the injury site and adjacent segments over sham injury levels. While the largest [mRNA]Cath B… CONTINUE READING
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