Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages.

Abstract

We previously showed that the one-electron reduction product of nitric oxide (NO), nitroxyl (HNO), irreversibly inhibits the proteolytic activity of the model cysteine protease papain. This result led us to investigate the differential effects of the nitrogen oxides, such as nitroxyl (HNO), NO, and in situ-generated peroxynitrite on cysteine modification… (More)

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@article{Vnnen2006CathepsinBI, title={Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages.}, author={Antti V{\"a}{\"a}n{\"a}nen and Pertteli Salmenper{\"a} and Mika V J Hukkanen and Pekka V. Rauhala and Esko Kankuri}, journal={Free radical biology & medicine}, year={2006}, volume={41 1}, pages={120-31} }