Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

@inproceedings{Matarrese2010CathepsinBI,
  title={Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study},
  author={P. Matarrese and Barbara Ascione and Laura Ciarlo and Rosa Vona and Carlo Leonetti and Marco Scarsella and Anna Maria Mileo and Caterina Catrical{\'a} and Marco G. Paggi and Walter Malorni},
  booktitle={Molecular Cancer},
  year={2010}
}
Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g. cathepsin D), normally present inside the lysosomes as inactive proenzymes. Once released in the extracellular space, cathepsins contribute to metastatic potential by facilitating cell migration and invasiveness. In the present work we first evaluated, by in vitro procedures, the role of cathepsins… CONTINUE READING
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Antiproliferative effect of benzophenones and their influence on cathepsin activity

  • RM Murata, R Yatsuda, +6 authors PL Rosalen
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  • 2010
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