Cathepsin B expression and localization in glioma progression and invasion.

  title={Cathepsin B expression and localization in glioma progression and invasion.},
  author={Sandra A. Rempel and Marc L. Rosenblum and Tom Mikkelsen and Pearlly Yan and K D Ellis and William A. Golembieski and Mansoureh Sameni and Jurij Rozhin and Gismar Ziegler and Bonnie F Sloane},
  journal={Cancer research},
  volume={54 23},
The poor prognosis of human malignant gliomas is due to their invasion and recurrence, the molecular mechanisms of which remain poorly characterized. We have accumulated substantial evidence implicating the cysteine protease cathepsin B in human glioma malignancy. Increases in cathepsin B expression were observed throughout progression. In primary brain tumor tissue, transcript abundance (Northern blot analysis) increased in low-grade astrocytoma to high-grade glioblastoma from 3- to 6-fold… CONTINUE READING
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