Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures.

Abstract

In cystic fibrosis (CF) lung disease, the absence of functional CF transmembrane conductance regulator results in Cl(-)/HCO3 (-) hyposecretion and triggers Na(+) hyperabsorption through the epithelial Na(+) channel (ENaC), which contribute to reduced airway surface liquid (ASL) pH and volume. Prostasin, a membrane-anchored serine protease with trypsin-like… (More)
DOI: 10.1113/jphysiol.2013.267286

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