Cathepsin B and its role(s) in cancer progression.

  title={Cathepsin B and its role(s) in cancer progression.},
  author={Izabela Podgorski and Bonnie F Sloane},
  journal={Biochemical Society symposium},
Experimental and clinical evidence has linked cathepsin B with tumour invasion and metastasis. Cathepsin B expression is increased in many human cancers at the mRNA, protein and activity levels. In addition, cathepsin B is frequently overexpressed in premalignant lesions, an observation that associates this protease with local invasive stages of cancer. Increased expression of cathepsin B in primary cancers, and especially in preneoplastic lesions, suggests that this enzyme might have pro… CONTINUE READING