Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages.

  title={Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages.},
  author={Avinash Sonawane and Jos{\'e} Carlos Santos and Bibhuti Bhusan Mishra and Prajna Jena and Cinzia Progida and Ole E Sorensen and Richard M. Gallo and Rui Appelberg and Gareth Griffiths},
  journal={Cellular microbiology},
  volume={13 10},
Macrophages have been shown to kill Mycobacterium tuberculosis through the action of the antimicrobial peptide cathelicidin (CAMP), whose expression was shown to be induced by 1,25-dihydroxyvitamin D3 (1,25D3). Here, we investigated in detail the antimycobacterial effect of murine and human cathelicidin against Mycobacterium smegmatis and M. bovis BCG infections. We have synthesized novel LL-37 peptide variants that exhibited potent in vitro bactericidal activity against M. smegmatis, M. bovis… CONTINUE READING


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