Cathelicidin LL‐37: a defense molecule with a potential role in psoriasis pathogenesis

@article{Dombrowski2012CathelicidinLA,
  title={Cathelicidin LL‐37: a defense molecule with a potential role in psoriasis pathogenesis},
  author={Y. Dombrowski and J. Schauber},
  journal={Experimental Dermatology},
  year={2012},
  volume={21}
}
Abstract:  Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are one family of AMPs in skin with various further immune functions. Consequently, dysfunction of these peptides has been implicated in the pathogenesis of inflammatory skin disease. In particular, the cathelicidin LL‐37 is overexpressed in inflamed skin in psoriasis, binds to extracellular self‐DNA released from dying cells and… Expand
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