Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

@inproceedings{Beaumont2014CathelicidinHD,
  title={Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo},
  author={Paula E Beaumont and Brian McHugh and Emily L Gwyer Findlay and Annie Mackellar and Karen J. Mackenzie and Richard L Gallo and John R. W. Govan and Andrew John George Simpson and Donald J Davidson},
  booktitle={PloS one},
  year={2014}
}
Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence against infection. In addition to microbicidal potential, these peptides have properties with the capacity to modulate inflammation and immunity. However, the extent to which such properties play a significant role during infection in vivo has remained unclear. A murine model of acute P. aeruginosa lung infection was utilised… CONTINUE READING

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