Catha edulis (Khat): In Vitro Culture and the Production of Cathinone and Other Secondary Metabolites

  title={Catha edulis (Khat): In Vitro Culture and the Production of Cathinone and Other Secondary Metabolites},
  author={H. M. Elhag and J. S. Mossa},
Khat, Catha edulis (Vahl) Forssk. ex Endl. (Celasteraceae), is an evergreen shrub or tall tree that may reach up to 25 m in height if not pruned (Fig. 1). Extensive pruning makes it a small shrub, as it is usually described. Its life span may extend for 40 years. The plant is indigenous to East Africa and southern Arabia, but may have originated in the Harar district of Ethiopia, according to earlier reports (Getahun and Krikorian 1973). Its habitat extends from northern Ethiopia to the… Expand
Antimicrobial and Cytotoxic Activity of the Extracts of Khat Callus Cultures
In the course of the work with khat tissue cultures, the production of dark colored pigments was observed as a typical characteristic of the callus culture, and the present investigation deals with the isolation, identification, and biological effects of such pigments. Expand
Enhanced HIV‐1 Reverse Transcriptase Inhibitory and Antibacterial Properties in Callus of Catha edulis Forsk.
Tissue culture‐derived calli could be used as therapeutic agents for traditional medicine and the choice of treatment used in the tissue culture system and the age of the callus for production of biomass may significantly influence its therapeutic potential. Expand


In Vitro Propagation of Catha edulis
In vitro propagation of khat is described to provide reliable and uniform plant material for further studies on secondary plant products and to investigate its pharmacological properties. Expand
The chewing of khat in Somalia.
  • A. S. Elmi
  • Medicine
  • Journal of ethnopharmacology
  • 1983
An epidemiological research to compare Northern and Southern regions of Somalia and to obtain a rough estimate of prevalence, definition of social characteristics of the groups of consumers, specification of the motivations, patterns of use and effects during and after consumption has been conducted. Expand
Studies on (−)-cathinone formation in micropropagated plants and tissue cultures of Catha edulis (Khat)
Callus growth was best obtained in the light on media containing 3.0 mg/1 IBA or NAA and the inclusion of 1.0 g/1 of PVP in the medium was found necessary to reduce the effects of pigments and to enhance callus growth. Expand
Alkaloids of catha edulis(khat). Part 1. Isolation and characterisation of eleven new alkaloids with sesquiterpene cores (cathedulins); identification of the quinone–methide root pigments
Extraction of fresh and dried specimens of Catha edulis(khat) originating from Ethiopia, Kenya, and the Yemen, has led to the isolation of eleven new celastraceous alkaloids having molecular weightExpand
The content of psychoactive phenylpropyl and phenylpentenyl khatamines in Catha edulis Forsk. of different origin.
In many samples a good correlation between the amount of cathinone, the main CNS-active compound, and quality estimation (price) of dealers and consumers was found. Expand
Flavan-3-ols and proanthocyanidins from Cistus incanus
Abstract Four monomeric and seven oligomeric flavanoids have been identified from a Cistus incanus subspecies traditionally used for treatment of skin diseases in northern parts of Greece andExpand
Medical aspects of the chewing of khat leaves.
  • H. Halbach
  • Medicine
  • Bulletin of the World Health Organization
  • 1972
Intoxication with khat is self-limiting but chronic consumption can cause certain disturbances to the health of the user and may also lead to social and economic damage to the individual and the community. Expand
The morphology and anatomy of the leaves of Catha edulis Forsk. obtained from Ethiopia is described and illustrated. A list of the characters of powdered Khat is also given.
Khat: pharmacognostical aspects.
  • A. Nordal
  • Biology, Medicine
  • Bulletin on narcotics
  • 1980
The vital organs (leaves, flowers, fruit and seeds) are described, with illustrations, to assist in the identification of khat. Expand
Handbook of Medicinal Herbs, Second Edition
Alphabetical listing of medicinal herbs by common name. About the author: James A. Duke, Ph.D. Economic Botanist, USDA is a Phi Beta Kappa graduate of the University of North Carolina, Chapel Hill,Expand