Catestatin decreases macrophage function in two mouse models of experimental colitis.

@article{Rabbi2014CatestatinDM,
  title={Catestatin decreases macrophage function in two mouse models of experimental colitis.},
  author={Mohammad Fazle Rabbi and Benoit Labis and Marie-H{\'e}l{\'e}ne Metz-Boutigue and Charles N Bernstein and Jean-Eric Ghia},
  journal={Biochemical pharmacology},
  year={2014},
  volume={89 3},
  pages={
          386-98
        }
}
  • Mohammad Fazle Rabbi, Benoit Labis, +2 authors Jean-Eric Ghia
  • Published in Biochemical pharmacology 2014
  • Medicine
  • Mucosal inflammation in patients with inflammatory bowel disease (IBD) is characterized by an alteration of prohormone chromogranin A (CgA) production. The recent demonstration of an implication of CgA in collagenous colitis and immune regulation provides a potential link between CgA-derived peptides (catestatin, CTS) and gut inflammation. Colitis was induced by administration of dextran sulfate sodium or 2, 4 dinitrobenzenesulfonic acid to C57BL/6 mice. Treatment with human (h)CTS or its… CONTINUE READING

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