Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.

@article{Aung2011CatestatinAN,
  title={Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.},
  author={Gyi Aung and François Niyonsaba and Hiroko Ushio and Naoki Kajiwara and Hirohisa Saito and Shigaku Ikeda and Hideoki Ogawa and Ko Okumura},
  journal={Immunology},
  year={2011},
  volume={132 4},
  pages={527-39}
}
Catestatin, a neuroendocrine peptide with effects on human autonomic function, has recently been found to be a cutaneous antimicrobial peptide. Human catestatin exhibits three single nucleotide polymorphisms: Gly364Ser, Pro370Leu and Arg374Gln. Given reports indicating that antimicrobial peptides and neuropeptides induce mast cell activation, we postulated that catestatin might stimulate numerous functions of human mast cells, thereby participating in the regulation of skin inflammatory… CONTINUE READING
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