Category: Methodology: Quantification and test-retest study of 11C-(R)-rolipram, a PET tracer of the cAMP cascade, using an arterial input function and an image-derived input function


Methods: Twelve healthy humans had two scans. Using metabolite-corrected arterial input, total distribution volume (VT) was measured with an unconstrained two-tissue compartment model and the Logan plot. Image input was derived from PET images of the internal carotid artery (the concentration of total radioactivity in blood) and from four arterial blood… (More)
DOI: 10.1016/j.neuroimage.2010.04.131