Categorizing biases in high-confidence high-throughput protein-protein interaction data sets.

@article{Yu2011CategorizingBI,
  title={Categorizing biases in high-confidence high-throughput protein-protein interaction data sets.},
  author={Xueping Yu and Joseph Ivanic and Vesna Memi{\vs}evi{\'c} and Anders Wallqvist and Jaques Reifman},
  journal={Molecular & cellular proteomics : MCP},
  year={2011},
  volume={10 12},
  pages={M111.012500}
}
We characterized and evaluated the functional attributes of three yeast high-confidence protein-protein interaction data sets derived from affinity purification/mass spectrometry, protein-fragment complementation assay, and yeast two-hybrid experiments. The interacting proteins retrieved from these data sets formed distinct, partially overlapping sets with different protein-protein interaction characteristics. These differences were primarily a function of the deployed experimental technologies… CONTINUE READING
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