Categorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers

@inproceedings{Malueka2012CategorizationO7,
  title={Categorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers},
  author={Rusdy Ghazali Malueka and Yutaka Takaoka and Mariko Yagi and Hiroyuki Awano and Tomoko Lee and Ery Kus Dwianingsih and Atsushi Nishida and Yasuhiro Takeshima and Masafumi Matsuo},
  booktitle={BMC Genetics},
  year={2012}
}
Duchenne muscular dystrophy, a fatal muscle-wasting disease, is characterized by dystrophin deficiency caused by mutations in the dystrophin gene. Skipping of a target dystrophin exon during splicing with antisense oligonucleotides is attracting much attention as the most plausible way to express dystrophin in DMD. Antisense oligonucleotides have been designed against splicing regulatory sequences such as splicing enhancer sequences of target exons. Recently, we reported that a chemical kinase… CONTINUE READING
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