Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human.

@article{Clark2002CategorizationAC,
  title={Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human.},
  author={Francis Clark and Thangavel Alphonse Thanaraj},
  journal={Human molecular genetics},
  year={2002},
  volume={11 4},
  pages={451-64}
}
By spliced alignment of human DNA and transcript sequence data we constructed a data set of transcript-confirmed exons and introns from 2793 genes, 796 of which (28%) were seen to have multiple isoforms. We find that over one-third of human exons can translate in more than one frame, and that this is highly correlated with G+C content. Introns containing adenosine at donor site position +3 (A3), rather than guanosine (G3), are more common in low G+C regions, while the converse is true in high G… CONTINUE READING

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