Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.

@article{Wuest2009CatecholaminesRD,
  title={Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.},
  author={Melinda Wuest and Birgit Eichhorn and Marc O Grimm and Manfred P Wirth and Ursula Ravens and Alberto Julio Kaumann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={328 1},
  pages={213-22}
}
(-)-Isoproterenol [4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzene diol hydrochloride] relaxes murine detrusor through beta-adrenoceptors (ARs); however, the beta-AR subtypes involved are unknown. beta(2)-ARs have been associated with caveolae, plasma-lemmal scaffolding domains that are absent in caveolin-1 (cav-1) knockout (KO) mice. Here, we studied detrusor responses in the absence and presence of beta-AR subtype-selective antagonists in wild-type (WT) and cav-1 KO mice. To inquire… CONTINUE READING
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