Catecholamines participate in the induction of ornithine decarboxylase gene expression in normal and hyperplastic mouse kidney.

@article{Dudkowska1999CatecholaminesPI,
  title={Catecholamines participate in the induction of ornithine decarboxylase gene expression in normal and hyperplastic mouse kidney.},
  author={Magdalena Dudkowska and Małgorzata Manteuffel-Cymborowska and Wanda Chmurzyńska and Barbara Grzelakowska-Sztabert},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1454 1},
  pages={
          71-9
        }
}
In the quinazoline antifolate (CB 3717)-induced hyperplastic kidney model, a remarkable increase of ornithine decarboxylase (ODC) activity was paralleled by a smaller, but highly significant augmentation of the ODC transcript level. Catecholamine depletion, evoked by reserpine, strongly impaired antifolate-induced ODC expression; the enzyme activity was almost completely abolished while the mRNA level decreased by 60%. Moreover, under conditions of a depleted catecholamine pool, kidney… CONTINUE READING
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